Low-pass CMOS Sigma-Delta Converter

A crescente necessidade em dar-se uma melhor saúde à população obriga ao desenvolvimento de novos e melhores dispositivos médicos. Atualmente, uma área de desenvolvimento importante é a de dispositivos portáteis para análise de sinais biológicos, tais como o eletrocardiograma ou o electroencefalograma, ajudando os profissionais de saúde a fazer rápidos diagnósticos no terreno, ou mesmo para serem usados por cidadãos que necessitem de vigilância constante. O desenvolvimento destes aparelhos traz novos desafios para a comunidade cientifica, nomeadamente na interface analógico/digital, na qualidade dos dados obtidos e no gasto energético. Para se conceber um bom dispositivos médico é necessário um conversor analógico/digital para frequências baixas, com baixo consumo energético e elevada resolução. Esta dissertação começa por fornecer ao leitor a teoria básica sobre conversores analógico/digital (ADC) e estado de arte. Como principal objetivo do trabalho desenvolvido, é descrito o desenho de um ADC baseado numa arquitetura Sigma-Delta que vá de encontro aos requisitos mencionados. O conversor foi implementado numa tecnologia 130 nm CMOS, usando uma frequência de amostragem de 1 MHz, com uma largura de banda de 1 kHz e tensão de alimentação 1,2 V. É usada, nos integradores do sigma-delta, uma invulgar tipologia de Opamp de forma a obter um ganho elevado, sem recurso a técnicas cascode. O quantizador possui uma resolução de 1,5 bits e é realizado com dois comparadores dinâmicos, de forma a minimizar o consumo energético.The growing need to provide better health for the population requires the development of new and better medical devices. Portable devices for the analysis of biological signals, such as the electrocardiogram or electroencephalogram, is nowadays an important development, helping health professionals to come up with fast diagnoses on the field, or even for use by citizens who require constant vigilance . Developing these devices brings new challenges to the scientific community, namely at the analog/digital interface, the quality of data and power consumption. In order to design a good medical device it is necessary an analog/digital converter for low frequencies, with low power consumption and high resolution. This dissertation begins by providing the reader with the basic theory of analog/digital (ADC) and its state of the art. The main goal of the work is the design of an ADC based on a Sigma-Delta architecture that meets the necessary medical requirements. The converter was implemented in a 130 nm CMOS technology using a sampling frequency of 1 MHz, with a bandwidth of 1 kHz, and a source voltage of 1.2 V. The integrators of sigma-delta employs an unusual Opamp typology in order to reach a high gain, without resourcing to cascode techniques. The quantizer has a resolution of 1.5 bits and is realized with two dynamic comparators, in order to minimize power consumption

Parecer sobre a realização de actividades Todo o Terreno nas escombreiras da Mina da Panasqueira

Parecer, elaborado em parceria, apresentado a diversas entidades, na sequência de notícia da SIC sobre actividades denominadas de radicais nas Escombreiras da Mina da Panasqueira

Assessment of calcinosis in Portuguese patients with systemic sclerosis: a multicenter study

© The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2023Introduction/objectives: The study aims to define the clinical and subclinical calcinosis prevalence, the sensitivity of radiographed site and clinical method for its diagnosis, and the phenotype of Portuguese systemic sclerosis (SSc) patients with calcinosis. Method: A cross-sectional multicenter study was conducted with SSc patients fulfilling Leroy/Medsger 2001 or ACR/EULAR 2013 classification criteria, registered in the Reuma.pt. Calcinosis was assessed through clinical examination and radiographs of hands, elbows, knees, and feet. Independent parametric or non-parametric tests, multivariate logistic regression, and sensitivity calculation of radiographed site and clinical method for calcinosis detection were performed. Results: We included 226 patients. Clinical calcinosis was described in 63 (28.1%) and radiological calcinosis in 91 (40.3%) patients, of which 37 (40.7%) were subclinical. The most sensitive location to detect calcinosis was the hand (74.7%). Sensitivity of the clinical method was 58.2%. Calcinosis patients were more often female (p = 0.008) and older (p < 0.001) and had more frequently longer disease duration (p < 0.001), limited SSc (p = 0.017), telangiectasia (p = 0.039), digital ulcers (p = 0.001), esophageal (p < 0.001) and intestinal (p = 0.003) involvements, osteoporosis (p = 0.028), and late capillaroscopic pattern (p < 0.001). In multivariate analysis, digital ulcers (OR 2.63, 95% CI 1.02-6.78, p = 0.045) predicted overall calcinosis, esophageal involvement (OR 3.52, 95% CI 1.28-9.67, p = 0.015) and osteoporosis (OR 4.1, 95% CI 1.2-14.2, p = 0.027) predicted hand calcinosis, and late capillaroscopic pattern (OR 7.6, 95% CI 1.7-34.9, p = 0.009) predicted knee calcinosis. Anti-nuclear antibody positivity was associated with less knee calcinosis (OR 0.021, 95% CI 0.001-0477, p = 0.015). Conclusions: Subclinical calcinosis high prevalence suggests that calcinosis is underdiagnosed and radiographic screening might be relevant. Multifactorial pathogenesis may explain calcinosis predictors' variability. Key Points • Prevalence of subclinical calcinosis in SSc patients is substantial. • Hand radiographs are more sensitive to detect calcinosis than other locations or clinical method. • Digital ulcers were associated with overall calcinosis, esophageal involvement and osteoporosis were associated with hand calcinosis, and late sclerodermic pattern in nailfold capillaroscopy was associated with knee calcinosis. • Anti-nuclear antibody positivity may be a protective factor for knee calcinosis.info:eu-repo/semantics/publishedVersio

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved